IDENTIFICATION OF NOVEL CHEMICAL SCAFFOLDS THAT INHIBIT THE GROWTH OF MYCOBACTERIUM TUBERCULOSIS IN MACROPHAGES

Identification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages

Mycobacterium tuberculosis is an important global pathogen for which new drugs are urgently required.The ability of the organism to survive and multiply within macrophages may contribute to the lengthy treatment regimen with multiple Dog Pack drugs that are required to cure the infection.We screened the MyriaScreen II diversity library of 10,000 co

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Acceptability of test and treat with doxycycline against Onchocerciasis in an area of persistent transmission in Massangam Health District, Cameroon.

The main onchocerciasis elimination strategy is annual Community-Directed Treatment with ivermectin (CDTi).However, as a response to persistent high infection prevalence in Massangam Health District in Cameroon, two rounds of alternative treatments including biannual CDTi, ground larviciding and test and treat with doxycycline (TTd) were implemente

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First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort

Background: Hypertensive disorders of pregnancy (HDP) such as preeclampsia and gestational hypertension are major contributors to maternal and child morbidity and mortality.Previous studies have reported associations with selected metals and vitamins but are limited in sample size and non-prospective study designs.We evaluated prospective associati

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